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Tumor-specific T-cell memory: clearing the regulatory T-cell hurdle

Anik L Côté1, Edward J Usherwood, Mary Jo Turk

  • 1Department of Microbiology and Immunology, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.

Cancer Research
|March 15, 2008
PubMed
Summary

Regulatory T-cells (T(reg)) limit antitumor immunity and prevent T-cell memory generation. Overcoming T(reg) suppression may enhance long-lasting immune responses against tumors after surgery.

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