Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic theory of working memory.

Gianluigi Mongillo1, Omri Barak, Misha Tsodyks

  • 1Group for Neural Theory, Département d'Etudes Cognitives, Ecole Normale Supérieure et Collège-de-France, Paris, France.

Science (New York, N.Y.)
|March 15, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When predict can also explain: Few-shot prediction to select better neural latents.

PLoS computational biology·2025
Same author

Interactions between long- and short-term synaptic plasticity transform temporal neural representations into spatial.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Corrigendum to "Mathematical models of learning and what can be learned from them" [Curr Opin Neurobiol 80 (2023)].

Current opinion in neurobiology·2025
Same author

Random Tree Model of Meaningful Memory.

Physical review letters·2025
Same author

Information rate of meaningful communication.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Large-scale study of human memory for meaningful narratives.

Learning & memory (Cold Spring Harbor, N.Y.)·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Working memory may be sustained by calcium-mediated synaptic facilitation, not just persistent neural firing. This calcium buffer mechanism is metabolically efficient and robust for maintaining information.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Neuroscience

Background:

  • Working memory is crucial for cognitive functions.
  • Persistent spiking activity is the traditionally assumed neural basis for working memory.
  • Existing models face challenges in explaining metabolic efficiency and robustness.

Purpose of the Study:

  • To propose an alternative mechanism for working memory maintenance.
  • To investigate the role of calcium dynamics in neocortical networks for working memory.
  • To offer a metabolically efficient and robust model of working memory.

Main Methods:

  • Theoretical modeling of synaptic facilitation.
  • Analysis of calcium kinetics in recurrent neocortical networks.

Related Experiment Videos

  • Simulations exploring the impact of spontaneous activity on memory duration.

    • Main Results:

    • Calcium-mediated synaptic facilitation provides a plausible buffer for working memory.
    • This mechanism allows for low refresh rates, enhancing metabolic efficiency.
    • Network spontaneous activity can dynamically regulate working memory duration and stability.

    Conclusions:

    • Working memory may be underpinned by calcium dynamics rather than solely persistent spiking.
    • This calcium-based model offers a more metabolically efficient and robust explanation.
    • Modulating network activity presents a potential pathway for controlling working memory parameters.