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Related Experiment Video

Updated: Jul 6, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.

Erica D Smith¹, Mitsuhiro Tsuchiya, Lindsay A Fox

¹Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

Genome Research

|March 15, 2008

Summary

Longevity genes are conserved across species, with 15% of yeast gene deletions linked to longer life spans, suggesting conserved aging pathways from yeast to mammals.

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Measuring Replicative Life Span in the Budding Yeast

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Published on: June 25, 2009

Area of Science:

Evolutionary biology
Genetics
Gerontology

Background:

Invertebrate model organisms have identified numerous aging genes, but their conservation in mammalian aging remains unclear.
Understanding conserved longevity pathways is crucial for aging research and potential interventions.

Purpose of the Study:

To quantitatively analyze the conservation of longevity genes between yeast (Saccharomyces cerevisiae) and the nematode (Caenorhabditis elegans).
To investigate whether aging pathways are conserved across highly divergent eukaryotic species.

Main Methods:

Comparative functional genomics approach.
Analysis of replicative life span phenotypes for single-gene deletions of yeast orthologs of worm aging genes.

Main Results:

15% of yeast ortholog deletions showed increased longevity, significantly higher than the 3.4% in random deletion mutants.
Genes involved in nutrient sensing and protein translation pathways were enriched among conserved longevity genes.
Several novel conserved aging genes potentially involved in new longevity pathways were identified.

Conclusions:

Genetic components of life span determination are significantly conserved between divergent eukaryotic species like yeast and C. elegans.
Conserved pathways, particularly those linking nutrient sensing and protein translation, are important for longevity.
These findings suggest conserved aging mechanisms relevant to mammalian aging research.