Postresuscitation myocardial stunning and its outcome: new approaches

What is the successful cardiopulmonary resuscitation? It is the few minutes postcardiopulmonary arrest that can answer. Twenty to 40 percent of patients who sustained cardiac arrest are initially resuscitated, but only 10% survive to hospital discharge, and more than 60% of victims succumb within 24 hours. This high fatality rate in the early hours and days after successful resuscitation is mainly related to the acute, intense, and reversible form of postresuscitation myocardial dysfunction (stunning) together with the ventricular tachyarrhythmia. It is a reversible process, provided that we are aware of the pertinent pathophysiology and then intervene accordingly. Herein I reviewed most of the published relevant articles concerning the causes, underlying mechanism, and the updated trials for management of postresuscitation myocardial stunning. I do agree that not only the restoration of the circulation but also long-term outcome should be the aim of resuscitation, and I readdress the role of epinephrine, dobutamine, biphasic defibrillator, with the new promising agent (ie, potassium channel opener), Delta-opioid receptor agonist, unloading intracellular calcium, antioxidants, and therapeutic hypothermia to halt this period of stunning. This will improve the outcome of the resuscitation efforts.