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Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of

,

    MMWR. Morbidity and Mortality Weekly Report
    |March 15, 2008
    PubMed

    Insights

    The combination measles, mumps, rubella, and varicella (MMRV) vaccine may increase the risk of febrile seizures in young children. The Advisory Committee on Immunization Practices (ACIP) updated recommendations to no longer prefer MMRV over separate vaccines.

    Area of Science:

    • Pediatric Vaccinology
    • Immunology
    • Public Health

    Background:

    • The combination measles, mumps, rubella, and varicella (MMRV) vaccine (ProQuad) was developed for convenient administration.
    • Concerns have been raised regarding the risk of febrile seizures in children following MMRV vaccination.
    • The Advisory Committee on Immunization Practices (ACIP) previously recommended MMRV over separate vaccines.

    Purpose of the Study:

    • To summarize current knowledge on the risk of febrile seizures associated with MMRV vaccination.
    • To present updated ACIP recommendations based on new safety information.
    • To inform healthcare providers and the public about vaccine safety and recommendations.

    Main Methods:

    • Review of existing data and new information presented to ACIP.
    • Analysis of the risk for febrile seizures in children aged 12-23 months after MMRV vaccination.
    • Development of updated immunization recommendations.

    Main Results:

    • New information indicated a risk for febrile seizures among children aged 12-23 months after MMRV vaccination.
    • The updated recommendations address the safety profile of the MMRV vaccine.
    • The previous preference for MMRV over separate vaccines was removed.

    Conclusions:

    • The ACIP has revised its recommendations regarding the MMRV vaccine.
    • The updated guidance reflects a shift away from preferring the combination vaccine due to safety concerns.
    • Separate administration of measles, mumps, and rubella (MMR) vaccine and varicella vaccine is now an alternative to consider.

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