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Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa
Ijaz Ahmad1, Shilin Chen, Yong Peng
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing, China. drijaz_chem@yahoo.com
Journal of Enzyme Inhibition and Medicinal Chemistry
|March 18, 2008
Abstract:
Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM.
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