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Microplate-compatible biamperometry array for parallel 48-channel amperometric or coulometric measurements.

Thomas S Mann1, Liam O'Hagan, Peter Ertl

  • 1Rapid Laboratory Microsystems Incorporated, Freeport Health Centre, P.O. Box 9056, 3570 King Street East, Kitchener, Ontario, Canada N2P 2G5.

Analytical Chemistry
|March 18, 2008
PubMed
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A novel reusable electrochemical array enables rapid, parallel biamperometric measurements in standard microplates. This high-throughput system accurately quantifies various analytes and enzymes, offering a precise and cost-effective solution for biochemical assays.

Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Biotechnology

Background:

  • Standard electrochemical methods can be time-consuming and lack high-throughput capabilities.
  • Parallel analysis is crucial for increasing efficiency in biochemical assays and diagnostics.

Purpose of the Study:

  • To develop and validate a reusable electrochemical array for parallel biamperometric measurements.
  • To demonstrate the array's utility in quantifying various oxidizable species and in enzymatic assays.

Main Methods:

  • Design of a 48-channel electrochemical array using platinum wire electrodes in a standard 96-well microplate format.
  • Biamperometric detection employing potassium ferricyanide as an oxidant for various analytes.
  • Application to enzymatic assays, exemplified by glucose oxidase for glucose quantitation.

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Main Results:

  • Accurate quantitation of acetaminophen, ascorbic acid, hydroquinone, trolox, and uric acid with detection limits down to 1 microM.
  • Linearity observed up to 100 microM for tested analytes.
  • Achieved a detection limit of 0.1 mM for glucose in enzymatic assays within 20 minutes.

Conclusions:

  • The developed electrochemical array offers a simple, precise, and rapid high-throughput method for biochemical analysis.
  • The array is suitable for a wide range of applications, including oxidase-based assays.
  • The use of standard microplates makes this a cost-effective and versatile tool.