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Published on: May 4, 2018
Manganous phosphate acts as a superoxide dismutase
Kevin Barnese1, Edith B Gralla, Diane E Cabelli
1Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095-1569, USA.
Journal of the American Chemical Society
|March 18, 2008
Summary
Manganous ions offer radiation resistance and antioxidant protection. Manganous phosphate uniquely removes superoxide via a novel catalytic mechanism, distinct from superoxide dismutase (SOD) enzymes.
Area of Science:
- Biochemistry
- Cell Biology
- Radiation Biology
Background:
- High intracellular manganous ions confer resistance to ionizing radiation.
- Manganous ions provide antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes.
Purpose of the Study:
- To investigate the unique properties of manganous phosphate in removing superoxide.
- To elucidate the mechanism by which manganous phosphate interacts with superoxide.
Main Methods:
- Studied various manganous salts for their ability to remove superoxide from aqueous solutions.
- Characterized the catalytic mechanism of manganous phosphate in superoxide removal.
Main Results:
- Manganous phosphate demonstrated a unique ability to rapidly and catalytically remove superoxide.
- The observed mechanism of superoxide removal by manganous phosphate is distinct from that of SOD enzymes.
Conclusions:
- Manganous phosphate possesses unique superoxide scavenging properties.
- The catalytic mechanism of manganous phosphate offers a novel pathway for antioxidant protection, distinct from endogenous SOD enzymes.
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