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Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures

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Published on: May 31, 2024

Evaporative self-assembly from complex DNA-colloid suspensions.

Lu Zhang¹, Siddharth Maheshwari, Hsueh-Chia Chang

¹Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.

Langmuir : the ACS Journal of Surfaces and Colloids

|March 18, 2008

Summary

Evaporation drives pattern formation in DNA-colloid mixtures. Particle size and concentration control ring structures, enabling hybrid material fabrication.

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Area of Science:

Materials Science
Soft Matter Physics
Nanotechnology

Background:

Evaporation-induced pattern formation is key for self-assembly in diverse applications.
Research has primarily focused on single-component systems, leaving multicomponent systems underexplored.

Purpose of the Study:

Investigate evaporation-induced interfacial hydrodynamics and self-assembly in DNA-colloid binary suspensions.
Understand how competing intermolecular and interfacial interactions influence pattern formation in multicomponent systems.

Main Methods:

Utilized a DNA-colloid binary suspension as a model system.
Employed direct microscopic observations to analyze pattern formation during droplet evaporation.

Main Results:

High DNA and low colloid concentrations favor multiple-ring patterns.
Increasing colloidal particle size disrupts rings, forming rippled or curtain-like patterns with spoke structures.
Oppositely charged colloids increase DNA-colloid interaction, leading to irregular ring spacing.

Conclusions:

Local hydrodynamics, influenced by colloid aggregation and sedimentation, govern pattern disruption.
Demonstrated the feasibility of creating periodic self-assembled hybrid structures through one-step evaporation of multicomponent droplets.