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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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Related Experiment Video

Updated: Jul 6, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Growth factors, stem cells, and stroke.

Haviryaji S G Kalluri1, Robert J Dempsey

  • 1Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA.

Neurosurgical Focus
|March 18, 2008
PubMed
Summary

Post-stroke brain repair involves neurogenesis, where factors influence neural stem cell activity. Understanding these growth factors is key to developing new stroke therapies and improving patient outcomes.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stroke Research

Background:

  • Post-stroke brain repair involves neurogenesis, the creation of new neurons.
  • Ischemic tissue releases factors that influence neural stem cell (NSC) behavior.
  • Some factors stimulate, while others inhibit, neurogenesis after stroke.

Purpose of the Study:

  • To review the roles of growth factors and stem cells in post-stroke neurogenesis.
  • To elucidate how different factors modulate NSC proliferation, differentiation, and migration.
  • To highlight the therapeutic potential of understanding these neurogenic mechanisms.

Main Methods:

  • Literature review of studies on growth factors and stem cells in stroke models.
  • Analysis of the differential effects of specific growth factors on neurogenesis.

More Related Videos

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells
05:49

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells

Published on: April 13, 2018

Related Experiment Videos

Last Updated: Jul 6, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells
05:49

Electrically Conductive Scaffold to Modulate and Deliver Stem Cells

Published on: April 13, 2018

  • Discussion of the interplay between various factors influencing neural repair.

    • Main Results:

    • Growth factors like insulin-like growth factor-I and fibroblast growth factor-2 (FGF-2) differentially affect NSC proliferation and differentiation.
    • Transforming growth factor-beta can promote neuronal differentiation while inhibiting NSC proliferation.
    • The balance of stimulatory and inhibitory factors is crucial for effective neurogenesis.

    Conclusions:

    • Understanding the specific roles of each factor is essential for enhancing endogenous repair mechanisms after stroke.
    • Targeting these factors offers potential therapeutic strategies to improve clinical outcomes.
    • Further research into growth factor signaling pathways can guide the development of novel stroke treatments.