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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jul 6, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Intravascular cell replacement therapy for stroke.

Raphael Guzman1, Raymond Choi, Atul Gera

  • 1Department of Neurosurgery, Stanford University Medical Center, Stanford, California, USA.

Neurosurgical Focus
|March 18, 2008
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for stroke recovery. Intravascular delivery, rather than direct brain injection, is a viable option, with research focusing on optimal timing and mechanisms for neuroprotection and repair.

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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

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Last Updated: Jul 6, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Biomedical Engineering

Background:

  • Stroke remains a leading cause of long-term disability.
  • Stem cell transplantation is an emerging therapeutic strategy for neurological repair.
  • Optimal delivery methods and timing for stem cell transplantation post-stroke are still under investigation.

Purpose of the Study:

  • To review the potential of intravascular stem cell delivery for stroke treatment.
  • To explore the optimal timing and mechanisms of intravascular stem cell therapy.
  • To discuss current in vivo imaging techniques for tracking transplanted stem cells.

Main Methods:

  • Literature review focusing on intravascular stem cell delivery post-stroke.
  • Analysis of studies on transendothelial migration, neuroprotection, angiogenesis, immunomodulation, and neural plasticity.
  • Examination of current in vivo imaging and cell tracking methodologies.

Main Results:

  • Intravascular stem cell delivery presents a viable alternative to intracerebral transplantation.
  • Evidence suggests specific timing and mechanisms enhance therapeutic effects.
  • In vivo imaging aids in understanding stem cell behavior and efficacy.

Conclusions:

  • Intravascular stem cell delivery is a promising approach for stroke therapy.
  • Further research into optimal delivery parameters and mechanisms is crucial.
  • Advanced imaging techniques will facilitate clinical translation of stem cell therapies for stroke.