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Updated: Jul 6, 2026
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
Published on: October 24, 2016
Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with
Daniela Simon1, Sol Naranjo Moreno, Johannes Hirschberger
1Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30173 Hannover, Germany.
Objective:
To compare response rates and remission and survival times in dogs with lymphoma treated with a continuous, multiagent, doxorubicin-based chemotherapeutic protocol or with a short-term single-agent protocol incorporating doxorubicin.
Design:
Nonrandomized controlled clinical trial.
Animals:
114 dogs with lymphoma.
Procedures:
Dogs were treated with a chemotherapeutic protocol consisting of L-asparaginase, vincristine, cyclophosphamide, doxorubicin, methotrexate, and prednisolone (n=87) or doxorubicin alone (27).
Results:
63 of 86 (73%) dogs treated with the multiagent protocol (data on response was unavailable for 1 dog) and 14 of 27 (52%) dogs treated with the single-agent protocol had a complete remission. Dogs with lymphoma classified as substage
Conclusions And Clinical Relevance:
In this population of dogs, we were not able to identify any significant difference in remission or survival times between dogs with lymphoma treated with a continuous, multiagent chemotherapeutic protocol and dogs treated with a short-term single-agent protocol involving doxorubicin.
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