Related Experiment Video
Updated: Jul 6, 2026

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
HPV type infection in different anogenital sites among HIV-positive Brazilian women
Maria Alice G Gonçalves1, Giorgia Randi, Annie Arslan
1Division of Clinical Immunology, University of São Paulo, São Paulo, Brazil. epigin@uol.com.br
Objectives:
To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV).
Goal:
Compare the prevalence of different HPV types and the risk factors for HPV positivity in three sites.
Results:
The most frequently detected HPV types in all sites were, in decreasing order, HPV16, 53, 18, 61 and 81. Agreement between the cervix and vagina was good (kappa 0.60 - 0.80) for HPV16 and 53 and excellent (Kappa > 0.80) for HPV18 and 61. HPV positivity was inversely associated with age for all combinations including the anal site.
Conclusion:
In HIV positive women, HPV18 is the most spread HPV type found in combinations of anal and genital sites. The relationship of anal to genital infection has implications for the development of anal malignancies. Thus, the efficacy of the current HPV vaccine may be considered not only for the cervix, but also for prevention of HPV18 anal infection among immunossuppressed individuals.
Related Concept Videos
Genital Herpes
Sexually Transmitted Infections
Herpes
Trichomoniasis
Candidiasis
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
