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On the nature of thumbs
Günter P Wagner1, Alexander O Vargas
1Department of Ecology and Evolutionary Biology, Yale University, Prospect Street, New Haven, CT 06520-8106, USA. gunter.wagner@yale.edu
Abstract:
Asymmetric regulation of Hox gene expression pre-dates the appearance of tetrapod digits, and was co-opted in the development of 'thumbness'. This asymmetric expression correlates with independent morphological evolutionary variation of digit 1.
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