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Laterality in schizophrenia. A reaction time study.

J Fishman¹, F Schwartz, E Bertuch

¹Department of Psychiatry, Cornell University Medical College, New York Hospital.

European Archives of Psychiatry and Clinical Neuroscience

|January 1, 1991

Summary

Schizophrenia patients show altered reaction times (RT) related to psychoticism, particularly in their right hand. This effect is task-dependent, suggesting state-dependent, not permanent, brain hemisphere deficits.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Schizophrenia is often associated with cognitive deficits and lateralization abnormalities.
Understanding the nature of these deficits (state-dependent vs. permanent) is crucial for treatment.

Purpose of the Study:

To investigate the relationship between psychoticism and reaction time (RT) laterality in schizophrenia.
To determine if observed laterality effects are state-dependent or indicative of permanent cortical dysfunction.

Main Methods:

Measured RT in individuals with schizophrenia and a control group under baseline and concurrent task conditions.
Assessed clinical measures of psychoticism.

Main Results:

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In schizophrenia patients, higher psychoticism correlated with slower right-hand RT in the baseline condition, an effect not seen in controls.

A concurrent task reduced the impact of psychoticism on RT performance, mitigating the laterality effect.

Conclusions:

Left-hemisphere deficits in schizophrenia may be state-dependent, influenced by cognitive load.
These findings suggest that observed laterality differences may not solely stem from fixed cortical dysfunction.