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Multitasking of interferon regulatory factor-4 in early B cells

Peter Nielsen1, Rudolf Grosschedl

  • 1Max Planck Institute of Immunobiology, Freiburg, Germany.

Immunity
|March 18, 2008
PubMed

Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling.

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