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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

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Is feline foamy virus really apathogenic?

A C German¹, D A Harbour, C R Helps

¹School of Clinical Veterinary Science, University of Bristol, Langford BS40 5DU, United Kingdom. Allison.German@liverpool.ac.uk

Veterinary Immunology and Immunopathology

|March 18, 2008

Summary

Experimental feline foamy virus (FFV) infection in cats showed persistent viraemia and subclinical kidney and lung pathology. Further research is needed before using FFV as a gene therapy vector.

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Area of Science:

Veterinary Virology
Retroviral Research
Gene Therapy Vectors

Background:

Feline foamy virus (FFV) is a retrovirus in cats, often considered non-pathogenic.
Its potential as a gene therapy vector is explored, but associations with arthritis and FIV cofactor effects exist.

Purpose of the Study:

To investigate experimental FFV infection in cats.
To determine if FFV infection is associated with clinical signs of disease.

Main Methods:

Eight specific pathogen-free cats were inoculated with FFV.
Monitoring included twice-weekly examinations, blood/pharyngeal sampling, haematology, biochemistry, and FFV qPCR.
Tissue samples were collected over six months for analysis.

Main Results:

FFV was detected in blood and pharyngeal samples, with two viraemia peaks observed.
All cats developed anti-FFV IgG antibodies.
Clinically, cats remained normal, but histopathology revealed mild glomerulonephritis and moderate interstitial pneumonia.

Conclusions:

Experimental FFV infection in cats leads to subclinical kidney and lung histopathological changes.
Despite apparent clinical normality, these findings warrant further investigation before FFV can be used as a gene therapy vector.