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Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Mumps.

Anders Hviid1, Steven Rubin, Kathrin Mühlemann

  • 1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. aii@ssi.dk

Lancet (London, England)
|March 18, 2008
PubMed
Summary
This summary is machine-generated.

Mumps, a vaccine-preventable viral infection, can cause complications like meningitis and deafness. Despite high vaccine effectiveness, outbreaks occur in vaccinated populations, particularly among young adults.

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Area of Science:

  • Virology
  • Epidemiology
  • Immunology

Background:

  • Mumps is a common childhood viral infection characterized by parotid gland swelling.
  • Complications include aseptic meningitis, encephalitis, orchitis, oophoritis, deafness, and pancreatitis.
  • Clinical diagnosis can be challenging due to variable symptoms and overlapping conditions.

Purpose of the Study:

  • To summarize the epidemiology and diagnosis of mumps.
  • To highlight the effectiveness and limitations of the mumps vaccine.
  • To discuss recent outbreaks in vaccinated populations.

Main Methods:

  • Literature review of mumps epidemiology and diagnosis.
  • Analysis of vaccine effectiveness and herd immunity concepts.
  • Examination of recent mumps outbreaks in the UK and USA.

Main Results:

  • Mumps diagnosis relies on clinical signs, viral detection, or serology (IgM antibodies).
  • The mumps vaccine is approximately 80% effective with one dose, and routine vaccination significantly reduces incidence.
  • Outbreaks have occurred in vaccinated populations, notably among young adults in the UK and USA, indicating challenges in achieving herd immunity.

Conclusions:

  • Mumps remains a public health concern despite vaccine availability.
  • Vaccine effectiveness and uptake are crucial for preventing outbreaks and achieving herd immunity.
  • Further strategies may be needed to address mumps transmission in specific populations.