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Updated: Jul 6, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Cutaneous plasmablastic lymphoma.

Anokhi Jambusaria¹, Danielle Shafer, Hong Wu

¹Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Journal of the American Academy of Dermatology

|March 18, 2008

Summary

This summary is machine-generated.

Plasmablastic lymphoma, a diffuse large B-cell lymphoma variant, rarely affects the skin. This report details an isolated cutaneous case in an HIV-positive individual with long-term follow-up.

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Last Updated: Jul 6, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

Oncology
Dermatology
Infectious Diseases

Background:

Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin lymphoma.
PBL predominantly affects immunocompromised individuals, particularly those with advanced HIV infection.
While systemic involvement is common, primary cutaneous PBL is exceptionally rare.

Observation:

This case study presents an unusual instance of isolated cutaneous plasmablastic lymphoma.
The patient was an HIV-positive man with a history of over 10 years.
The lymphoma exclusively manifested in the skin, with no evidence of systemic disease.

Findings:

The report documents a rare case of PBL presenting solely in the skin.
This finding contributes to the limited literature on cutaneous manifestations of PBL.
The patient's HIV status is a critical factor in understanding the disease's presentation.

Implications:

This case highlights the importance of considering PBL in the differential diagnosis of cutaneous lesions in immunocompromised patients.
Further research into isolated cutaneous PBL may improve diagnostic accuracy and treatment strategies.
Long-term follow-up of such cases is crucial for understanding disease progression and outcomes.