Assessment of coronary heart disease risk by combined analysis of coagulation factors

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Nena Aleksic1, Yao-Wei W Wang, Chul Ahn

  • 1Department of Internal Medicine at Medical School, Vascular Biology Research Center at Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, TX 77030, USA. nevenka.matijevic-aleksic@uth.tmc.edu

Atherosclerosis
|March 18, 2008
PubMed

Insights

Soluble thrombomodulin (sTM) interacts with fibrinogen, influencing coronary heart disease (CHD) risk. Combined analysis of these coagulation factors improves CHD risk assessment.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Epidemiology

Background:

  • Coagulation factors are linked to coronary heart disease (CHD) risk.
  • The interaction between these factors and CHD risk is not well understood.

Purpose of the Study:

  • To investigate interactions between soluble thrombomodulin (sTM) and other coagulation factors (fibrinogen, factor VIII, FVII, PAI-1) in relation to CHD risk.
  • To determine if combined analysis of these factors improves CHD risk prediction.

Main Methods:

  • Prospective case-cohort study design.
  • Cox proportional hazard regression analysis.
  • Analysis of interactions between sTM and fibrinogen, FVIII, FVII, and PAI-1 in 410 CHD cases and 721 non-cases from the ARIC study.

Main Results:

  • A significant interaction was found between sTM and fibrinogen (p=0.027).
  • High sTM levels counteracted CHD risk from high fibrinogen, while low sTM amplified it.
  • FVIII and PAI-1 showed positive associations with CHD risk in the context of low sTM.

Conclusions:

  • Complex interactions exist between sTM and prothrombotic coagulation factors.
  • Combined analysis of sTM and coagulation factors enhances CHD risk assessment.
Abstract

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