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Effects of sex steroids on beta-endorphin release from rat hypothalamus in vitro
1Department of Medicine, Tokyo Women's Medical College, Japan.
Brain Research
|July 5, 1991
Abstract:
The effects of sex steroids on immunoreactive beta-endorphin (EP) release from the rat hypothalamus in vitro were examined using a rat hypothalamic perifusion system and an EP RIA. Testosterone (1-100 ng/ml) and estradiol (10-100 pg/ml) stimulated EP release in a dose-dependent manner. Dehydroepiandrosterone (DHEA, 1-100 ng/ml) dose-dependently inhibited EP release. These results indicate an inverse relationship between the acute effect of gonadal sex steroids and that of adrenal androgen on hypothalamic EP release in vitro.