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Cerebrovascular and functional consequences of 5-HT1A receptor activation
D E McBean1, J Sharkey, I M Ritchie
1Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, U.K.
Brain Research
|July 26, 1991
Abstract:
Cerebral glucose utilization and blood flow were measured in rats using 2-deoxy-D-[14C]glucose and [14C]iodoantipyrine quantitative autoradiography, respectively, following treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). In control and 8-OH-DPAT-treated animals blood flow and glucose use were similarly correlated, but the ratio was increased following 8-OH-DPAT treatment. Since 5-HT1A receptor activation is known to reduce neuronal 5-HT release, these results are consistent with a vasoconstrictor role for endogenous serotonin.