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Related Experiment Video

Updated: Jul 6, 2026

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos
07:53

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos

Published on: August 3, 2012

Expression of MEGAP mRNA during embryonic development.

Robert Waltereit1, Sandra Kautt, Dusan Bartsch

  • 1Central Institute of Mental Health, Department of Molecular Biology, University of Heidelberg, J5, 68159 Mannheim, Germany.

Gene Expression Patterns : GEP
|March 18, 2008
PubMed
Summary

The MEGAP/SRGAP3 gene is crucial for brain development and function. Its expression pattern in mice supports its role in Rho-associated mental retardation (MR).

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Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Mental retardation (MR) affects up to 2% of the population, often linked to impaired learning and memory.
  • Mutations in genes within Rho signal transduction cascades are frequently associated with MR.
  • Rho pathways regulate neuronal development and synaptic plasticity.

Purpose of the Study:

  • To investigate the expression pattern of the mouse MEGAP/SRGAP3 mRNA during embryonic development.
  • To understand the role of MEGAP/SRGAP3 in the context of Rho-associated MR.

Main Methods:

  • In-situ hybridization was used to analyze MEGAP mRNA expression.
  • Analysis was performed on whole-mount mouse embryos and brain sections from embryonic day 10 (E10) to adulthood.

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Related Experiment Videos

Last Updated: Jul 6, 2026

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos
07:53

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos

Published on: August 3, 2012

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis
06:59

A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis

Published on: August 11, 2010

Tracing Gene Expression Through Detection of β-galactosidase Activity in Whole Mouse Embryos
08:42

Tracing Gene Expression Through Detection of β-galactosidase Activity in Whole Mouse Embryos

Published on: June 26, 2018

Main Results:

  • Robust MEGAP mRNA expression was observed throughout the central nervous system of E10 embryos.
  • MEGAP expression was detected in dorsal root ganglia at E12.
  • In adult animals, MEGAP expression was predominantly found in the hippocampus and cortex.

Conclusions:

  • The expression pattern of MEGAP mRNA in developing and adult mice supports its involvement in Rho-associated MR.
  • Findings suggest MEGAP/SRGAP3 plays a significant role in neural development relevant to cognitive functions.