Analytical methodologies for the determination of cisplatin

Area of Science:

• Pharmacology
• Analytical Chemistry
• Oncology

Background:

• Cisplatin (cis-Diamminedichloroplatinum(II)) has been a cornerstone chemotherapy agent since 1978.
• Severe side effects like nephrotoxicity and ototoxicity necessitate dose limitations (max 100 mg/m(2) over 21 days).
• Accurate quantification of cisplatin in biological matrices is essential for therapeutic drug monitoring and managing toxicity.

Purpose of the Study:

• To systematically review and present the most recent analytical techniques for determining cisplatin concentrations in biological samples.
• To highlight methods capable of achieving high sensitivity (part per billion levels) in native samples.

Main Methods:

• Literature search of recent analytical methodologies for cisplatin determination.
• Focus on techniques applicable to biological fluids and tissues.
• Emphasis on methods offering high accuracy and sensitivity.

Main Results:

• Various analytical methods have been developed for precise cisplatin quantification.
• These techniques enable detection at or below the part per billion level.
• The methods are suitable for analysis in native biological samples, minimizing pre-treatment.

Conclusions:

• Accurate analytical methods are critical for optimizing cisplatin dosage and minimizing patient toxicity.
• The review provides a valuable resource for researchers and clinicians seeking sensitive cisplatin detection techniques.
• Advancements in analytical chemistry continue to support the safe and effective use of cisplatin in cancer therapy.