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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

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Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Acute Myocardial Infarction in Rats
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Heart failure in acute ischemic stroke.

Angel Ois1, Meritxell Gomis, Elisa Cuadrado-Godia

  • 1Unit of Neurovascular Research, Neurology Department, Institut Municipal d'Investigació Mèdica - Hospital del Mar, Departament de Medicina, Universitat Autònoma de Barcelona, Spain. 94545@imas.imim.es

Journal of Neurology
|March 18, 2008
PubMed
Summary

Heart failure (HF) in acute ischemic stroke (AIS) patients, whether with preserved or decreased left ventricular function, independently predicts a poor outcome. This includes moderate-severe disability or death within 90 days.

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Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Acute ischemic stroke (AIS) poses significant health challenges.
  • Heart failure (HF) is a common comorbidity in AIS patients.
  • The impact of different HF types on AIS outcomes requires clarification.

Purpose of the Study:

  • To investigate the association between heart failure (HF) with preserved or decreased left ventricular function (LVF) and outcomes in acute ischemic stroke (AIS) patients.
  • To determine if HF impacts stroke severity and mortality.
  • To analyze risk factors associated with poor outcomes in AIS patients with HF.

Main Methods:

  • A cohort of 503 unselected AIS patients was studied.
  • Poor outcome was defined as moderate-severe disability or death at 90 days post-stroke.
  • Logistic regression analysis was employed to assess the association between HF types and poor outcomes, adjusting for confounders.

Main Results:

  • 17.7% of patients had HF (9.7% systolic HF, 8% HF with preserved LVF).
  • Patients with HF and preserved LVF were older, more likely female, and less likely to smoke compared to those with systolic HF.
  • An independent association was found between initial stroke severity, systolic HF (aOR=3.01), HF with preserved LVF (aOR=2.52), and poor outcome.

Conclusions:

  • Both systolic heart failure and heart failure with preserved left ventricular function are independently associated with poor outcomes in acute ischemic stroke patients.
  • These findings highlight the importance of managing HF in AIS patients to improve prognoses.
  • Further research may explore specific interventions for HF patients experiencing AIS.