Related Experiment Video

Updated: Jul 6, 2026

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

[Cardiac amyloidosis]

Caroline Hoyer1, Christiane E Angermann, Stefan Knop

  • 1Medizinische Klinik und Poliklinik I, Universität Würzburg, Klinikstrasse 6-8, Würzburg. Hoyer_C@klinik.uni-wuerzburg.de

Medizinische Klinik (Munich, Germany : 1983)
|March 18, 2008
PubMed

Insights

Amyloidosis involves amyloid fibril deposition in multiple organs, often affecting the heart and leading to severe complications. Treatment varies by type, including stem cell or liver transplantation for specific forms.

Area of Science:

  • Cardiology
  • Hematology
  • Nephrology
  • Neurology

Background:

  • Amyloidoses are multisystem disorders characterized by extracellular amyloid fibril deposition.
  • Cardiac involvement is common and a leading cause of mortality in amyloidosis patients.
  • Symptoms include edema, dyspnea, chest pain, and autonomic dysfunction.

Purpose of the Study:

  • To provide an overview of amyloidosis, focusing on cardiac involvement.
  • To discuss the common types of amyloidosis, including AL and ATTR.
  • To outline current and potential treatment strategies.

Main Methods:

  • Literature review of amyloidosis, cardiac manifestations, and treatment options.
  • Discussion of diagnostic criteria and therapeutic approaches for different amyloidosis subtypes.
  • Synthesis of information on AL amyloidosis, ATTR amyloidosis, and other forms.

Main Results:

  • AL amyloidosis, linked to monoclonal gammopathy, is the most common form, treatable with melphalan and stem cell transplantation.
  • ATTR amyloidosis, an autosomal dominant disorder, is curable with liver transplantation.
  • Cardiac amyloidosis management follows heart failure guidelines, with other types including senile systemic and secondary amyloidosis.

Conclusions:

  • Amyloidosis is a serious condition with significant cardiac implications.
  • Treatment selection is crucial, especially for high-mortality procedures like stem cell transplantation.
  • Multidisciplinary approaches are essential for managing this complex group of diseases.

More Related Videos

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...