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Published on: May 16, 2025

Clinical features of juvenile lupus erythematosus in Iranian children

M H Moradinejad1, G R Zamani, A R Kiani

  • 1Dep. of Rheumatology, Medical Sciences, University of Tehran, Tehran, Iran. swt_f@yahoo.com

Acta Reumatologica Portuguesa
|March 18, 2008
PubMed

Insights

Juvenile Systemic Lupus Erythematosus (JSLE) presents with diverse and severe clinical features, frequently involving skin, musculoskeletal, and renal systems. Early diagnosis is crucial for managing this complex pediatric autoimmune disease.

Area of Science:

  • Pediatric Rheumatology
  • Autoimmune Diseases
  • Clinical Immunology

Background:

  • Juvenile Systemic Lupus Erythematosus (JSLE) is a chronic autoimmune disease affecting children.
  • Understanding the clinical spectrum of JSLE is essential for timely diagnosis and management.
  • Previous studies highlight the variability in JSLE presentation and outcomes.

Purpose of the Study:

  • To analyze the clinical and laboratory features of childhood-onset Systemic Lupus Erythematosus (JSLE).
  • To describe the diverse organ involvement and severity in pediatric SLE patients.
  • To contribute to a better understanding of JSLE for improved diagnostic strategies.

Main Methods:

  • Retrospective multicenter study including 45 children diagnosed with JSLE before age 16.
  • Patients met the American College of Rheumatology (ACR) 1982 revised criteria for SLE.
  • Data collected on clinical manifestations, laboratory findings, and outcomes.

Main Results:

  • The female to male ratio was 8:1, with a mean age of onset at 10.5 years.
  • Common manifestations included skin (88.8%), musculoskeletal (77.7%), and renal (64.4%) involvement.
  • Significant rates of hematological (55.5%), cardiovascular (26%), central nervous system (17%), and pulmonary (11%) disease were observed.

Conclusions:

  • JSLE exhibits diverse and often severe clinical manifestations in children.
  • Early recognition and diagnosis are critical for managing JSLE.
  • Further multicenter studies in varied geographic regions are needed to enhance understanding and diagnosis of JSLE.
Abstract

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