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Updated: Jul 6, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Optic neuropathy associated with dengue fever.

S Sanjay¹, A M Wagle, K G Au Eong

¹Department of Ophthalmology and Visual Sciences, Alexandra Hospital, Singapore, Singapore. Sanjay_S@alexhosp.com.sg

Eye (London, England)

|March 18, 2008

Summary

Dengue fever can cause optic neuropathy, leading to vision loss. While some vision may recover, severe and permanent visual impairment is possible in affected patients.

Area of Science:

Ophthalmology
Infectious Diseases
Neurology

Background:

Dengue fever is a mosquito-borne viral infection prevalent in tropical and subtropical regions.
Ocular complications of dengue fever are uncommon but can be severe.
Optic neuropathy is a potential neurological complication affecting vision.

Observation:

This case series reports on three patients diagnosed with dengue fever who developed optic neuropathy.
Patients presented with unilateral blurred vision within a week of dengue diagnosis.
Visual acuity varied significantly, with two patients exhibiting bilateral ocular signs.

Findings:

Presenting visual acuities ranged from counting fingers to 6/6.
Outcomes included partial recovery (6/9), severe vision loss (no light perception), and no change.

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The findings highlight the unpredictable nature of visual recovery in dengue-associated optic neuropathy.

Implications:

Optic neuropathy is a serious complication of dengue fever that requires prompt recognition.
Early detection and management may influence visual outcomes.
This condition underscores the importance of ophthalmological evaluation in patients with neurological symptoms post-dengue infection.