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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...

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Related Experiment Video

Updated: Jul 6, 2026

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Redefining the serotonergic system by genetic lineage.

Patricia Jensen1, Anna F Farago, Rajeshwar B Awatramani

  • 1Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Nature Neuroscience
|March 18, 2008
PubMed
Summary

Central serotonin neurons exhibit diversity, but their underlying molecular differences remain unclear. This study defines new serotonergic neuron subtypes based on progenitor cell genetic programs, revealing a molecular framework for this system.

Related Experiment Videos

Last Updated: Jul 6, 2026

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Central serotonin-producing neurons are known to be heterogeneous.
  • This heterogeneity manifests in location, morphology, neurotoxin sensitivity, and links to clinical disorders.
  • The molecular underpinnings and distinguishing markers of these serotonergic neuron subtypes are largely unknown.

Purpose of the Study:

  • To redefine serotonergic neuron subtypes based on distinct genetic programs.
  • To uncover a molecular framework for the serotonergic system.
  • To identify genetically defined subtypes for future manipulation.

Main Methods:

  • Analysis of genetic programs enacted in progenitor cells.
  • Characterization of molecular differences between serotonergic neuron subtypes.

Main Results:

  • Identification of distinct genetic programs that define serotonergic neuron subtypes.
  • Establishment of a molecular framework for the serotonergic system based on genetic lineage.
  • Demonstration of a method to access genetically defined serotonergic neuron subtypes.

Conclusions:

  • Serotonergic neuron heterogeneity can be classified based on progenitor genetic programs.
  • A genetic lineage-based molecular framework provides physiological relevance for serotonergic neuron subtypes.
  • This approach enables the study and manipulation of specific, genetically defined serotonergic neuron populations.