Related Experiment Videos
Sweat gland abnormalities in lichenoid dermatosis
1Department of Histopathology, RPMS, Hammersmith Hospital, London, UK.
Histopathology
|October 1, 1991
Summary
This study reveals that sweat glands are frequently affected in lichenoid dermatoses, showing abnormalities in 78% of cases. These changes, including cell vacuolation and duct hyperplasia, suggest primary involvement in conditions like lichen planus and drug eruptions.
Area of Science:
- Dermatology
- Pathology
Background:
- Lichenoid dermatosis affects the dermoepidermal junction.
- Skin appendage involvement is typically limited to hair follicles.
- Sweat gland involvement is not well-described in common lichenoid conditions.
Purpose of the Study:
- To investigate sweat gland abnormalities in common lichenoid dermatoses.
- To determine the prevalence and nature of sweat gland involvement.
Main Methods:
- Morphological analysis of 59 skin biopsy cases.
- Inclusion of lichen planus, discoid lupus erythematosus, fixed drug eruption, and erythema multiforme.
- Detailed examination of sweat gland structures.
Main Results:
- 78% (47/59) of cases exhibited sweat gland abnormalities.
- Abnormalities included cytoplasmic vacuolation, apoptosis, and ductal hyperplasia.
- Involvement primarily affected the excretory ducts near the acrosyringium.
Conclusions:
- Sweat gland abnormalities are common in lichenoid dermatoses.
- These findings suggest primary involvement of sweat glands in the disease process.
- This contrasts with secondary structural changes seen in other conditions.