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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

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[Brain tumors and pregnancy].

José Carlos Lynch¹, João Cláudio Emmerich, Sara Kislanov

¹Serviço de Neurocirurgia, Hospital dos Servidores do Estado do Rio de Janeiro, Brasil. cneuroamericas@uol.com.br

Arquivos De Neuro-Psiquiatria

|March 18, 2008

Summary

Pregnancy-related brain tumors, particularly meningiomas, can worsen during gestation. Optimal surgical timing for brain tumors during pregnancy depends on maternal health, tumor type, and fetal development.

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Area of Science:

Neuro-oncology
Maternal-Fetal Medicine
Neurosurgery

Background:

Brain tumors during pregnancy are rare but pose significant risks to both mother and fetus.
Meningiomas are the most common intracranial tumors observed in pregnant patients.
Pregnancy can exacerbate the clinical progression of existing brain tumors.

Observation:

A case series of 6 pregnant patients with brain tumors was reviewed.
Tumor management involved craniotomy and neurosurgical tumor removal.
Delivery timing relative to surgery varied, with some patients delivering before and others after the procedure.

Findings:

Meningioma was the predominant histological type among the studied brain tumors.
No operative mortality was recorded in this series, indicating safe surgical outcomes.
Pregnancy appears to influence the clinical course of intracranial tumors, potentially worsening symptoms.

Implications:

The optimal timing for neurosurgical intervention in pregnant patients with brain tumors is multifactorial.
Management decisions should integrate maternal neurological status, tumor histology, and gestational age.
Individualized treatment strategies are crucial for optimizing outcomes in this high-risk obstetric population.