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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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A Small-Scale Setup for Algal Toxicity Testing of Nanomaterials and Other Difficult Substances
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Temporal decrease of trivalent chromium concentration in a standardized algal culture medium: experimental results

Davide A L Vignati1, Mamadou L Beye, Janusz Dominik

  • 1University of Geneva Institut F.-A. Forel, Versoix, 1290, Switzerland. davide.vignati@terre.unige.ch

Bulletin of Environmental Contamination and Toxicology
|March 18, 2008
PubMed
Summary

Trivalent chromium salts rapidly decrease in algal culture media during toxicity tests. Monitoring chromium(III) levels is essential for accurately assessing its toxicity to algae.

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Published on: July 10, 2015

Area of Science:

  • Environmental Science
  • Ecotoxicology
  • Analytical Chemistry

Background:

  • Trivalent chromium [Cr(III)] is a metal of environmental concern.
  • Algal toxicity tests are standard for evaluating aquatic contaminants.
  • The stability of Cr(III) in test media can influence toxicity results.

Purpose of the Study:

  • To investigate the stability and fate of trivalent chromium salts in algal culture medium.
  • To determine Cr(III) concentration changes over a typical 72-hour algal toxicity test duration.
  • To highlight the importance of monitoring Cr(III) variability in ecotoxicity studies.

Main Methods:

  • Two trivalent chromium salts (nitrate and chloride) were added to ISO algal culture medium.
  • Cr(III) concentrations were monitored over a 72-hour period.
  • Temporal changes in dissolved Cr(III) were quantified.

Main Results:

  • A significant loss of initial Cr(III) was observed within 24 hours.
  • Up to 90% of the added chromium was lost from the solutions by 72 hours.
  • Concentrations of Cr(III) showed high temporal variability.

Conclusions:

  • Trivalent chromium is unstable in standard algal culture media.
  • Observed Cr(III) losses necessitate monitoring during toxicity assessments.
  • Accurate characterization of chromium toxicity to algae requires accounting for its dynamic behavior in test media.