Related Experiment Video
Updated: Jul 6, 2026
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
[Uncommon case of paraganglioma syndrome in combination with malignant paraganglioma]
K Schmahl1, N Atamna, T Schönijahn
1Abt. XIII, Pathologie, Bundeswehrzentralkrankenhaus Koblenz.
Background:
Combination of paraganglioma syndrome and malignant paraganglioma is an uncommon disease worldwide.
Patient:
We report the case of a 69-year old man with a jugular-tympanal paraganglioma, who underwent surgery. Histopathological examination revealed a malignant paraganglioma. An other contralateral carotid-body and a tumor in the thyroid gland had been discovered during staging. The molecular results confirmed the existence of a paraganglioma syndrome.
Discussion:
A malignant paraganglioma based on a hereditary paraganglioma syndrome is a rare described case in literature. On the background of the literature we discuss the pathology, pathogenesis, diagnostic and therapy of this disease.