Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From micro to macro: modulating the properties of cationic lamellar phases with nanocelluloses.

Journal of colloid and interface science·2026
Same author

Influence of Sugar Headgroup on the Self-Assembly of Bioinspired Anionic Glycolipids.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Complex Coacervate Emulsions as a Strategy to Stabilize Enzymes for Catalysis in Organic Solvents.

ACS macro letters·2025
Same author

Effect of the Chemical Structure of Ionic Glycolipids on Their Lyotropic Aqueous Phase Behavior.

ACS omega·2025
Same author

Miscibility and phase behavior in bulk and micellar systems of surfactant-polymer coacervate mixtures.

Journal of colloid and interface science·2025
Same author

Structural interplay in block copolymer-bile salt complexes: from globules to ribbons.

Soft matter·2025

Related Experiment Video

Updated: Jul 6, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Polysaccharide-based hydrogels: preparation, characterization, and drug interaction behaviour.

Eunice F S Vieira1, Antonio R Cestari, Claudio Airoldi

  • 1Laboratory of Materials and Calorimetry, Departamento de Química/CCET, Universidade Federal de Sergipe, 49100-000, São Cristóvão, Brazil. eunice@ufs.br

Biomacromolecules
|March 19, 2008
PubMed
Summary

This study explored interactions between pyrimethamine (PYR) and novel drug delivery materials, oxidized alginate (ADA) and ADA-chitosan (ADA-Chit). Both materials effectively encapsulated PYR, showing promise for drug formulation.

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Related Experiment Videos

Last Updated: Jul 6, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
09:30

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Physical Chemistry

Background:

  • Alginate and chitosan are biocompatible polymers with potential in drug delivery.
  • Oxidation of alginate and blending with chitosan can modify material properties.
  • Pyrimethamine is an antifolate drug requiring effective delivery systems.

Purpose of the Study:

  • To investigate the interaction between pyrimethamine and novel oxidized alginate (ADA) and ADA-chitosan (ADA-Chit) materials.
  • To characterize the thermodynamic parameters of these interactions.
  • To assess the encapsulation efficiency of pyrimethamine using these materials.

Main Methods:

  • Preparation of oxidized alginate (ADA) and ADA-chitosan (ADA-Chit) blends.
  • Tablet formulation with a mean diameter of 1.2 cm.
  • Isothermal titration calorimetry (ITC) to study drug-material interactions in DMSO.
  • UV spectrophotometry to determine pyrimethamine encapsulation efficiency.

Main Results:

  • Enthalpy changes of interaction (Delta int H) were determined: -11.73 kJ/mol for ADA and -4.86 kJ/mol for ADA-Chit.
  • High pyrimethamine encapsulation efficiency of approximately 75% was achieved for both ADA and ADA-Chit.
  • ITC revealed specific thermodynamic interactions between pyrimethamine and the prepared materials.

Conclusions:

  • Oxidized alginate and ADA-chitosan blends demonstrate favorable interactions with pyrimethamine.
  • These materials show significant potential for the encapsulation and delivery of pyrimethamine.
  • The study provides valuable thermodynamic data for optimizing drug formulation with these biomaterials.