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Related Experiment Video

Updated: Jul 6, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Paroxetine.

Siu Wa Tang¹, Daiga Helmeste

¹University of California, Psychiatry North Campus Zot 1681, Irvine, California 92697-1681, USA. swtang@uci.edu

Expert Opinion on Pharmacotherapy

|March 19, 2008

Summary

This summary is machine-generated.

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), is effective for various affective disorders but carries risks. Concerns include increased suicidality in young adults and potential side effects like serotonin syndrome.

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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

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Published on: November 27, 2016

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Last Updated: Jul 6, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Area of Science:

Pharmacology
Psychiatry
Clinical Therapeutics

Background:

Paroxetine is a commonly prescribed antidepressant.
Concerns exist regarding its association with suicide risk in younger patients.

Purpose of the Study:

To review the pharmacology of paroxetine.
To evaluate the efficacy and safety of paroxetine in treating affective disorders.

Main Methods:

Conducted a comprehensive PubMed literature search.
Included searches on the FDA and GSK websites for paroxetine-related data.
Keywords: paroxetine, Paxil, serotonin transporter, clinical trials, depression, SSRI.

Main Results:

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) with no significant active metabolites.
Approved for major depressive disorder, panic disorder, OCD, social anxiety, PTSD, and generalized anxiety disorders (ages 18+).

Conclusions:

Paroxetine exhibits good selectivity as an SSRI.
Documented drug-drug interactions via the CYP enzyme system.
Acknowledged risks include increased suicidality in younger adults, teratogenicity, serotonin syndrome, and persistent pulmonary hypertension.