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Related Experiment Videos

HLA expression in basal cell carcinomas.

D Garcia-Plata1, E Mozos, M A Sierra

  • 1Department of Biochemistry, University of Córdoba, Spain.

Invasion & Metastasis
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Basal cell carcinomas show varied expression of MHC class I molecules, with most lacking these crucial immune markers. Reduced HLA-ABC expression correlates with lower tumor differentiation, impacting malignancy.

Area of Science:

  • Immunology
  • Oncology
  • Dermatopathology

Background:

  • Decreased Major Histocompatibility Complex (MHC) class I expression in tumor cells is linked to increased malignancy in various cancers.
  • MHC molecules play a critical role in immune surveillance by presenting antigens to T cells.

Purpose of the Study:

  • To investigate the expression patterns of HLA-ABC (MHC class I) and HLA-DR (MHC class II) in basal cell carcinomas (BCCs).
  • To explore the correlation between MHC molecule expression levels and histological differentiation in BCCs.
  • To analyze the presence and distribution of MHC class II antigens within the tumor microenvironment, particularly in infiltrating lymphocytes.

Main Methods:

  • Analysis of HLA-ABC and HLA-DR expression in 56 basal cell carcinoma samples using immunohistochemistry.

Related Experiment Videos

  • Assessment of tumor cell staining patterns for MHC class I and class II molecules.
  • Evaluation of the correlation between MHC expression levels and histological differentiation.
  • Identification and characterization of infiltrating mononuclear cells, focusing on T lymphocytes (CD-3 positive).
  • Examination of MHC class II expression in the tumor infiltrate.

    • Main Results:

    • Basal cell carcinomas exhibited heterogeneous MHC class I expression: 11% uniformly positive, 25% partially positive, and 64% negative.
    • A positive correlation was observed between higher levels of HLA-ABC expression and greater histological differentiation.
    • MHC class II (HLA-DR) expression was largely absent or weak in tumor cells (5% weak homogeneous, 32% focal, 63% negative).
    • Infiltrating mononuclear cells were predominantly T lymphocytes.
    • MHC class II molecules were expressed in the infiltrate of 68% of tumors.
    • Expression of MHC class II antigens in infiltrating lymphocytes correlated with tumor cell MHC class II expression, suggesting immune activation.

    Conclusions:

    • A significant proportion of basal cell carcinomas display reduced or absent MHC class I expression, potentially contributing to immune evasion.
    • The inverse relationship between HLA-ABC expression and tumor dedifferentiation suggests a role for MHC class I in BCC progression.
    • While tumor cells show limited MHC class II expression, the infiltrate often expresses these molecules, indicating an inflammatory response.
    • The correlation between lymphocyte and tumor cell MHC class II expression points to immune system engagement within the tumor microenvironment.