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Published on: August 7, 2017

Bronchial obstructive phenotypes in the first year of life among Paris birth cohort infants

Bénédicte Clarisse1, Christophe Demattei, Lydia Nikasinovic

  • 1Laboratoire Santé Publique et Environnement, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Paris, France.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|March 19, 2008
PubMed

Insights

This study identified two infant phenotypes with distinct respiratory symptoms, suggesting potential allergic and asthmatic outcomes. Close follow-up is recommended for these infants, considering environmental and behavioral risk factors.

Area of Science:

  • Pediatrics
  • Allergology
  • Respiratory Medicine

Background:

  • The natural history of early childhood respiratory and allergic diseases remains unclear.
  • Prospective studies are crucial for understanding symptom onset and progression.

Purpose of the Study:

  • To prospectively assess the onset of respiratory and allergic symptoms in early childhood.
  • To identify distinct infant phenotypes based on bronchial obstructive symptoms.

Main Methods:

  • A Paris birth cohort study involving 2698 infants.
  • Data collected via five questionnaires during the first year of life.
  • Partitioning around medoids (PAM) for infant classification and polytomous logistic regression for factor analysis.

Main Results:

  • Two distinct infant phenotypes (G1 and G2) were identified, comprising 8.7% and 23.5% of infants, respectively.
  • G2 infants exhibited severe bronchial obstructive disorders, while G1 infants had nocturnal dry cough.
  • Parental asthma history, rhino-conjunctivitis symptoms, and birth season differentiated the G1 group.

Conclusions:

  • Infants in G1 and G2 groups require close monitoring for potential allergic and asthmatic phenotypes.
  • Environmental and behavioral risk factors may play a role in the development of these conditions.

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