Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the skin sensitization potential of fragrance ingredients in consumer products using the peroxidase peptide reactivity assay (PPRA) as an additional weight of evidence.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same author

Development of a skin sensitization Site-of-Contact Exposure Threshold (SoCET) for botanicals and natural substances.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2025
Same author

Quantitative next generation risk assessment for skin sensitization - application of regression models based on in vitro data to estimate point of departure.

Regulatory toxicology and pharmacology : RTP·2025
Same author

Applicability Domain of Peroxidase Peptide Reactivity Assay (PPRA): Chemical Structure Analysis and Grouping of Peptide Depletion Patterns.

Chemical research in toxicology·2025
Same author

Predicting points of departure and potency categories for fragrance ingredients by integrating OECD in vitro models.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2024
Same author

Deriving a point of departure for assessing the skin sensitization risk of wearable device constituents with in vitro methods.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2024

Related Experiment Video

Updated: Jul 6, 2026

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
21:16

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model

Published on: July 13, 2009

Preservatives and skin sensitization quantitative risk assessment.

David A Basketter1, Catherine J Clapp, Bob J Safford

  • 1Unilever, Colworth House, Sharnbrook, Bedfordshire, UK.

Dermatitis : Contact, Atopic, Occupational, Drug
|March 19, 2008
PubMed
Summary

Quantitative risk assessment (QRA) helps predict safe exposure levels for preservatives, reducing allergic contact dermatitis (ACD) from consumer products. This method aids in setting acceptable limits for sensitizers, improving product safety.

More Related Videos

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
12:04

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

Published on: May 9, 2018

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Related Experiment Videos

Last Updated: Jul 6, 2026

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
21:16

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model

Published on: July 13, 2009

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
12:04

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

Published on: May 9, 2018

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

Area of Science:

  • Dermatology
  • Toxicology
  • Risk Assessment

Background:

  • Preservatives in cosmetics and medicaments are frequent causes of allergic contact dermatitis (ACD).
  • Quantitative risk assessment (QRA) is a newer method for determining safe exposure levels of sensitizers in consumer products.

Purpose of the Study:

  • To evaluate the effectiveness of QRA in predicting safe exposure levels for skin sensitizers.
  • To assess if QRA can identify acceptable levels below sensitization induction thresholds.

Main Methods:

  • A retrospective QRA was performed.
  • The analysis included four preservatives across five consumer product categories.

Main Results:

  • Preservative levels in some products may exceed ideal exposure thresholds.
  • These findings align with observed clinical presentations of ACD.

Conclusions:

  • QRA is a valuable tool for managing preservative-induced ACD.
  • Future use of QRA should integrate with microbial protection needs for specific products.