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Onycholysis associated with capecitabine in patients with breast cancer
Marcia Hogeling1, Jessica Howard, Nordau Kanigsberg
1Division of Dermatology, University of Ottawa, ON. hogelingm@yahoo.ca
Background:
Onycholysis, which is separation of the nail plate from the nail bed at its distal and lateral attachments, can cause pain and impair function and is a well-known side effect of traditional chemotherapeutic agents.
Objectives:
We present two cases of onycholysis associated with capecitabine in women with advanced breast cancer, who were initially referred for evaluation of onychomycosis and review the literature on capecitabine.
Conclusion:
Owing to the increased frequency of use of capecitabine for different cancers, physicians should be aware of this side effect.
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