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Updated: Jul 6, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
Impaired endothelial function in adolescents with type 1 diabetes mellitus
Farid H Mahmud1, Stan Van Uum, Nimira Kanji
1Division of Paediatric Endocrinology and Diabetes, Children's Hospital of Western Ontario, London, Ontario, Canada. mahmud@lhsc.on.ca
Objective:
To evaluate the effect of a high-fat meal on endothelial function in adolescents with type 1 diabetes mellitus (T1D).
Study Design:
Twenty-three children with T1D, aged 12 to 18 years, and age- and sex-matched healthy control subjects were assessed for baseline macronutrient intake, and endothelial function was measured both fasting and after a standardized fast-food, high-fat breakfast.
Results:
Endothelial function, assessed noninvasively by peripheral arterial tonometry, was impaired in the T1D group in the fasting state as compared with control subjects (T1D 1.78 +/- 0.4, control subjects 2.06 +/- 0.4, P = .02), and worsened postprandially in both groups (T1D 1.45 +/- 0.3, control subjects 1.71 +/- 0.3, P = .01). Both groups demonstrated significantly elevated triglyceride levels 3.5 hours after ingestion of the high-fat meal (T1D 114.8 +/- 42.8 and control subjects 126.7 +/- 54.9 mg/dL). Nutrient intake in both groups showed higher than recommended intakes of total fat, saturated fat, and cholesterol.
Conclusions:
Patients with T1D exhibited worse endothelial function both before and after a high-fat breakfast than their peers. This suggests that patients with T1D are at greater risk of vascular impairment after a high-fat meal, the cumulative effect of which may contribute to the higher atherosclerotic burden observed in T1D.
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