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Updated: Jul 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Is beta-thalassemia trait a protective factor against ischemic cerebrovascular accidents?
Mehran Karimi1, Afshin Borhani Haghighi, Maryam Yazdani
1Hematology Research Center, Nemazee Hospital, Shiraz, Iran. karimim@sums.ac.ir
Objective:
In this research, we sought to determine the association between beta-thalassemia trait and ischemic cerebrovascular accident (CVA).
Methods:
In acase-control study, 148 patients with thromboembolic cerebrovascular events were evaluated for the presence of hypertension, diabetes mellitus, hyperlipidemia, and beta-thalassemia trait. A total of 156 age- and sex-matched patients with no cardiac or cerebrovascular diseases, serving as the control group, were also investigated for the above-mentioned risk factors.
Results:
We found that 6.1% of patients with ischemic CVA and 12.2% of the control group had beta-thalassemia trait (P = .066). In male patients, the negative association between ischemic CVA and presence of beta-thalassemia trait was significant (P = .008). In patients, the prevalence of hypertension was also significantly different between those with and without beta-thalassemia trait (P = .01); those with beta-thalassemia trait had a lower mean blood pressure than those without the trait.
Conclusion:
beta-Thalassemia trait may have a protective effect against ischemic CVA that might be caused by the lower arterial blood pressure observed in those with this trait.
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