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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

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Left ventricular ejection fraction using 64-slice CT coronary angiography and new evaluation software: initial

M S Krishnam¹, A Tomasian, Michael Iv

¹Department of Radiology, David Geffen School of Medicine, University of California at Los Angeles, Peter V Ueberroth Bldg, Suite 3371, 10945 Le Conte Avenue, Los Angeles, CA 90095-7206, USA. mkrishnam@mednet.ucla.edu

The British Journal of Radiology

|March 19, 2008

Summary

Software for 64-slice CT coronary angiography reliably quantifies left ventricular function. This user-friendly tool offers rapid and reproducible ejection fraction (EF) measurements, comparable to echocardiography.

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Area of Science:

Cardiovascular imaging
Medical software development

Background:

Accurate assessment of left ventricular function is crucial for cardiovascular diagnosis.
Traditional methods for quantifying left ventricular function can be time-consuming.

Purpose of the Study:

To assess the feasibility and reliability of software-based quantification of left ventricular function.
To evaluate a specific software (Syngo Circulation I) for this purpose using 64-slice CT coronary angiography.

Main Methods:

Retrospective electrocardiogram-gated 64-slice CT coronary angiography data from 26 subjects were used.
A prototype software automatically segmented left ventricular blood volume at end diastole and end systole.
Left ventricular volumes, stroke volume, and ejection fraction (EF) were calculated. Intra- and inter-observer variability were assessed, and CT EF was compared to echocardiography.

Main Results:

The software demonstrated good intra-observer reproducibility for EF measurements (13.6% and 15.6%).
No significant inter-observer differences were found in left ventricular functional parameters.
CT-derived EF showed a slight mean difference compared to echocardiography, with values within acceptable agreement limits.

Conclusions:

Software-based quantification of left ventricular EF using 64-slice CT coronary angiography is feasible and reliable.
The evaluated software is user-friendly, rapid, and provides reproducible results.
This method offers a valuable alternative for assessing left ventricular function.