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Updated: Jul 6, 2026
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
[Side effects of FEC100]
Ayako Endo1, Takanori Watanabe, Hideaki Kodama
1Dept. of Surgery, National Hospital Organization Sendai Medical Center, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 19, 2008
Summary
FEC100 chemotherapy is generally tolerable for breast cancer patients, but bone marrow suppression is a significant concern, especially in those with multiple bone metastases. Careful monitoring is advised for this patient subgroup.
Area of Science:
- Oncology
- Pharmacology
- Clinical Medicine
Context:
- Breast cancer treatment regimens
- Chemotherapy side effect management
- Adjuvant and neoadjuvant therapies
Purpose:
- To evaluate the safety profile of FEC100 chemotherapy.
- To specifically assess bone marrow suppression, nausea, and vomiting.
- To identify patient subgroups at higher risk for adverse events.
Summary:
- FEC100 treatment in 49 breast cancer patients revealed a mean white blood cell nadir of 1,492/microL on day 13.
- Grade 4 leukopenia occurred in 16.3% of patients, with higher incidence (50%) in those with multiple bone metastases.
- Nausea affected 30.6% and vomiting 6.1% of patients; febrile neutropenia occurred in 8.1%.
Impact:
- FEC100 treatment is considered tolerable, but requires caution in patients with multiple bone metastases due to severe bone marrow suppression.
- Findings inform clinical practice regarding risk stratification and supportive care for breast cancer patients undergoing FEC100 chemotherapy.
- Highlights the need for vigilant monitoring of hematologic parameters and management of gastrointestinal side effects.
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