[Squamous cell carcinoma of the lower lip, completely responding to concurrent chemoradiotherapy with S-1]

Concurrent chemoradiotherapy (CCRT) can be used in order to increase both the local and systemic control of head and neck carcinoma. This report shows for the first time the assessment of CCRT with S-1 as a treatment modality for squamous cell carcinoma (SCC) of the lower lip. Surgical excision is usually the first choice for the treatment of SCC of the lower lip, followed by reconstruction. Such a treatment choice more or less compromises the cosmetic and/or functional status of the lip. We present our experience of utilizing CCRT with S-1 as a mode of treatment for SCC of the lower lip that yielded significant results while preserving the integrity of the lip.