Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Is Alba an RNase P subunit?

J Chris Ellis¹, Jeffrey Barnes, James W Brown

¹Laboratory of Signal Transduction, NIEHS, Research Triangle Park, North Carolina, USA.

|March 19, 2008

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lenalidomide plus rituximab for previously untreated advanced follicular lymphoma: the 10-year RELEVANCE trial analysis.

Blood·2026

Same author

Clinical outcomes of mature T- and NK-cell lymphomas in hepatitis B virus positive individuals: results from the PETAL Global Consortium.

Leukemia & lymphoma·2026

Same author

Disparities in immunotherapy treatment for mycosis fungoides and Sézary syndrome in the National Cancer Database.

Journal of the American Academy of Dermatology·2025

Same author

Short-duration infusion obinutuzumab with venetoclax in chronic lymphocytic leukemia: a prospective observational study.

Blood neoplasia·2025

Same author

Forecasting optimal treatments in relapsed/refractory mature T- and NK-cell lymphomas: A global PETAL Consortium study.

British journal of haematology·2025

Same author

Secondary Cancer Risk Among Patients With Primary Cutaneous B-cell Lymphoma.

JAMA dermatology·2025

Same journal

RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease.

RNA biology·2026

Same journal

Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids.

RNA biology·2026

Same journal

The role of RNA modifications in cancer translational control.

RNA biology·2026

Same journal

Discovery of a mutation-containing circRNA in polyglutamine disease through systematic analysis of RNAs with CAG repeats.

RNA biology·2026

Same journal

FDA-approved antisense oligonucleotide therapies for duchenne muscular dystrophy: current status and future outlook.

RNA biology·2026

Same journal

The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.

RNA biology·2026

See all related articles

Alba protein is not a subunit of archaeal RNase P holoenzyme. Biochemical assays found no association between Alba homologs and RNase P, nor did Alba enhance its activity.

Area of Science:

Biochemistry
Molecular Biology
Microbiology

Background:

Alba is a known chromatin protein in Archaea.
Human Alba homologs associate with RNase P, suggesting a similar role in Archaea.

Purpose of the Study:

To investigate if Alba is a subunit of the archaeal RNase P holoenzyme.
To determine the role of the Alba homolog (Mth1483p) in Methanothermobacter thermoautotrophicus.

Main Methods:

Utilized biochemical methods previously established for identifying archaeal RNase P subunits.
Tested for association between Mth1483p and the RNase P holoenzyme.
Assessed the effect of Mth1483p on the activity of reconstituted RNase P holoenzyme.

Main Results:

Related Experiment Videos

No association was detected between Mth1483p and the archaeal RNase P holoenzyme.
Mth1483p did not enhance the activity of the reconstituted RNase P holoenzyme.

Conclusions:

The study found no evidence supporting Alba as an RNase P subunit in Archaea.
The previously suggested role of Alba in archaeal RNase P is not supported by these findings.