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Updated: Jul 6, 2026

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Scattering differentiates Alzheimer disease in vitro
Eugene B Hanlon1, Lev T Perelman, Eduard I Vitkin
1Department of Veterans Affairs, Office of Research and Development, and Geriatric Research, Education and Clinical Center, 200 Springs Road, Bedford, Massachusetts 01730, USA. Eugene.Hanlon@med.va.gov
Abstract:
The molecular bases of Alzheimer disease and related neurodegenerative disorders are becoming better understood, but the means for definitive diagnosis and monitoring in vivo remain lacking. Near-infrared optical spectroscopy offers a potential solution. We acquired transmission and reflectance spectra of thin brain tissue slabs, from which we calculated wavelength-dependent absorption and reduced scattering coefficients from 470-1000 nm. The reduced scattering coefficients in the near infrared clearly differentiated Alzheimer from control specimens. Diffuse reflectance spectra of gross brain tissue in vitro confirmed this observation. These results suggest a means for diagnosing and monitoring Alzheimer disease in vivo, using near-infrared optical spectroscopy.
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