Related Experiment Video
Updated: Jul 6, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
Study on physicochemical properties and in vitro bioactivity of tricalcium silicate-calcium carbonate composite bone
1Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
Abstract:
In this article, a novel bone cement composed of tricalcium silicate (Ca(3)SiO(5); C(3)S) and calcium carbonate (CaCO(3)) was prepared with the weight percent of CaCO(3) in the range of 0, 10, 20, 30, and 40%. The initial setting time was dramatically reduced from 90 to 45 min as the content of CaCO(3) increased from 0 to 40%, and the workable paste with a liquid/powder (L/P) ratio of 0.8 ml/g could be injected between 2 and 20 min (nozzle diameter 2.0 mm). The composite cement showed higher mechanical strength (24-27 MPa) than that of the pure Ca(3)SiO(5) paste (14-16 MPa). Furthermore, the composite cement could induce apatite formation and degrade in the phosphate buffered saline. The results indicated that the Ca(3)SiO(5)-CaCO(3) paste had better hydraulic properties than pure Ca(3)SiO(5) paste, and also the composite cement was bioactive and degradable. The novel bone cement could be a potential candidate as a bone substitute.
Related Concept Videos
Hydration of Cement
Strength of Cement
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in ASTM C...
Soundness of Cement
Strength and Heat of Hydration
The heat of hydration for each cement compound is significant; for instance, tricalcium aluminate (C3A) and...
Fineness of Cement
Direct...
