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Published on: August 16, 2018
Two new lanostane triterpenoids from Poria cocos
1State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Journal of Asian Natural Products Research
|March 19, 2008
Summary
Researchers identified two novel lanostane triterpenoids and three known compounds from Poria cocos. These natural products were isolated and structurally elucidated using comprehensive spectroscopic methods.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Poria cocos (Schw.) Wolf, also known as Fu Ling, is a traditional medicinal fungus.
- Its sclerotium is widely used in herbal medicine for various health benefits.
- Investigating the chemical constituents of Poria cocos can lead to the discovery of novel bioactive compounds.
Purpose of the Study:
- To isolate and characterize new and known chemical compounds from the sclerotium of Poria cocos.
- To elucidate the structures of these isolated compounds using advanced spectroscopic techniques.
Main Methods:
- Extraction of Poria cocos sclerotium using 95% ethanol.
- Isolation of compounds using chromatographic techniques.
- Structure determination via extensive spectroscopic analyses: IR, UV, ESITOF-MS, HRESI-MS, 1D NMR (1H, 13C), and 2D NMR (1H-1H COSY, NOESY, HSQC, HMBC).
Main Results:
- Isolation of two new lanostane triterpenoids: 29-hydroxypolyporenic acid C and 25-hydroxypachymic acid.
- Isolation of three known compounds: ergosta-7,22-dien-3beta-ol, polyporenic acid C, and pachymic acid.
- Complete structural elucidation of all five isolated compounds.
Conclusions:
- The chemical investigation of Poria cocos yielded novel triterpenoids and known compounds.
- The structural characterization was achieved through rigorous spectroscopic analysis.
- This study contributes to the understanding of the phytochemical profile of Poria cocos.
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