Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Challenges in implementing CD4 testing in resource-limited settings.

Trevor Peter1, Anne Badrichani, Emily Wu

  • 1Clinton Foundation HIV/AIDS Initiative, 225 Water Street, Quincy, Massachusetts 02169, USA.

Cytometry. Part B, Clinical Cytometry
|March 19, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Palm Cooling's Heart Rate and Thermal Impact on Exercise in Multiple Sclerosis Patients.

Sports medicine international open·2026
Same author

Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The future of diagnostics in Africa.

Nature medicine·2026
Same author

Target trial emulation without matching: a more efficient approach for evaluating vaccine effectiveness using observational data.

Epidemiology (Cambridge, Mass.)·2026
Same author

Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings.

The Lancet. Microbe·2026
Same author

Global perspective on gaps in fungal diagnostics in low-resource settings: WHO landscape analysis and research priorities for invasive fungal diseases.

The Lancet. Microbe·2026
Same journal

What is the optimal threshold for aberrant lymphoblasts at diagnosis to predict lymphoid transformation in chronic myeloid leukemia?

Cytometry. Part B, Clinical cytometry·2026
Same journal

Quantifying interpretive contributions to analytical variability in clinical flow cytometry.

Cytometry. Part B, Clinical cytometry·2026
Same journal

Quantifying gating heterogeneity in the Ogata score: Implications for reproducibility and score-based diagnostics.

Cytometry. Part B, Clinical cytometry·2026
Same journal

DinoFlow: Self-supervised pretraining in flow cytometry enables accurate detection of common hematopathological disorders.

Cytometry. Part B, Clinical cytometry·2026
Same journal

Flow cytometric PD-L1 expression enhances identification of Reed-Sternberg cells in suspected Hodgkin lymphoma from lymph node biopsies.

Cytometry. Part B, Clinical cytometry·2026
Same journal

27-color flow cytometry for measurable residual disease detection in B-cell lymphoblastic leukemia.

Cytometry. Part B, Clinical cytometry·2026
See all related articles

The rapid scale-up of HIV diagnostics has improved patient monitoring but faced challenges in implementation. Lessons learned are strengthening laboratory systems for current and future diagnostic needs.

Area of Science:

  • Immunology
  • Public Health
  • Laboratory Medicine

Background:

  • The widespread adoption of antiretroviral therapy for HIV has increased the demand for CD4 and CD4% count diagnostics.
  • Accurate staging and monitoring of disease progression and treatment efficacy are crucial for both adults and infants.

Purpose of the Study:

  • To assess the scale-up of HIV diagnostic capacity.
  • To identify challenges encountered during the rapid implementation of CD4 testing.
  • To evaluate the impact of these challenges on laboratory systems and future diagnostic implementation.

Main Methods:

  • Review of the implementation process for CD4 and CD4% count diagnostics.
  • Analysis of challenges faced, including technology selection, infrastructure, human resources, cost, maintenance, access, and quality.

Related Experiment Videos

  • Assessment of lessons learned and their implications for laboratory systems.

    • Main Results:

    • Rapid scale-up of CD4 and CD4% count capacity has been achieved.
    • Significant challenges were encountered, including technology selection, infrastructure, human resources, cost-effectiveness, instrument maintenance, and quality assurance.
    • The experience has provided valuable lessons for strengthening laboratory systems.

    Conclusions:

    • The rapid implementation of HIV diagnostics, despite challenges, has enhanced laboratory capacity.
    • Lessons learned are vital for improving existing laboratory systems and facilitating the introduction of future diagnostics.
    • Strengthening laboratory systems is essential for effective HIV management and public health initiatives.