Related Experiment Video
Updated: Jul 6, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Unusual presentation of idiopathic osteosclerosis: a case report
Marcel Noujeim1, Samer Bsoul, Michaell Huber
1Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School, USA.
Abstract:
Idiopathic osteosclerosis (IO) typically manifests as an incidentally discovered, well-defined homogenous radiopacity that blends in with the surrounding bone. Once the condition is diagnosed, treatment is neither indicated nor necessary; however, atypical variants of osteosclerosis have been described and may pose a diagnostic and management dilemma for the clinician who encounters them. This case report discusses the differential conditions that should be considered when an atypical variant of IO is encountered. While the diagnosis in this case was fortuitously confirmed by biopsy, routine follow-up is the recommended course of action.
Related Concept Videos
Osteoclasts in Bone Remodeling
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...